Effects of epinephrine, clonidine, L-phenylephrine, and morphine on intestinal secretion mediated by Escherichia coli heat-stable enterotoxin in pig jejunum
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Published:1982-12-01
Issue:12
Volume:60
Page:1680-1685
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ISSN:0008-4212
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Container-title:Canadian Journal of Physiology and Pharmacology
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language:en
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Short-container-title:Can. J. Physiol. Pharmacol.
Author:
Ahrens Franklin A.,Zhu Bei Lei
Abstract
Perfusion of pig jejunum with Escherichia coli heat-stable enterotoxin (strain 1261) reversed net absorption of water and electrolytes to net secretion. Addition of the α-adrenergic agonists clonidine (5 × 10−7 M) or L-phenylephrine (5 × 10−6 M), or the opiate agonist morphine (3.6 × 10−6 M) to the perfusate reduced the secretory response to enterotoxin and stimulated absorption in normal jejunum. Epinephrine (5 × 10−5 M) did not stimulate absorption in controls but reduced chloride loss in the presence of enterotoxin. Mucosal sodium – potassium adenosine triphosphatase was unchanged but disaccharidase activity was decreased in the presence of enterotoxin. The results suggest that α-adrenergic agonists and opiate agonists may exert an antidiarrheal action by increasing net transport across intestinal epithelium.
Publisher
Canadian Science Publishing
Subject
Physiology (medical),Pharmacology,General Medicine,Physiology
Cited by
20 articles.
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