Molecular species of interferon induced in mice by poly I:C and Mengo virus

Abstract

The molecular weights of the interferons appearing in the serum of mice injected intravenously with Mengo virus and with poly I:C are about 28 000 and 45 000 respectively. Since there is evidence that some forms of interferon are more potent than others, it is suggested that molecular-weight estimations might provide a convenient marker for more systematic studies of the efficacy of interferon preparations and inducing substances for clinical use.