Is methylglyoxal a causative factor for hypertension development?This paper is one of a selection of papers published in this Special Issue, entitled Young Investigator's Forum.-Reference-Cited by-同舟云学术

Is methylglyoxal a causative factor for hypertension development?This paper is one of a selection of papers published in this Special Issue, entitled Young Investigator's Forum.

Published:2006-01 Issue:1 Volume:84 Page:129-139
ISSN:0008-4212
Container-title:Canadian Journal of Physiology and Pharmacology
language:en
Short-container-title:Can. J. Physiol. Pharmacol.

Author:

Wu Lingyun¹

Affiliation:

1. Department of Pharmacology, College of Medicine, University of Saskatchewan, A120 Health Sciences Building, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada (e-mail: ).

Abstract

Hypertension is a life-threatening disease that is associated with increased cardiovascular risks. Causes and mechanisms for hypertension development remain poorly understood. Methylglyoxal (MG), a highly reactive molecule, is a metabolite of sugar. Increased circulation and tissue levels of MG have been documented not only in diabetes but also in hypertension. Many recent studies also link MG-induced vascular damage to the pathogenic process of hypertension. As such, an etiological role of MG in hypertension development is proposed.

Publisher

Canadian Science Publishing

Subject

Physiology (medical),Pharmacology,General Medicine,Physiology

Link

http://www.nrcresearchpress.com/doi/pdf/10.1139/Y05-137

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