Somatic DNA recombination in the brainThis paper is one of a selection of papers published in this Special Issue, entitled The Nucleus: A Cell Within A Cell.-Reference-Cited by-同舟云学术

Somatic DNA recombination in the brainThis paper is one of a selection of papers published in this Special Issue, entitled The Nucleus: A Cell Within A Cell.

Published:2006-03 Issue:3-4 Volume:84 Page:319-324
ISSN:0008-4212
Container-title:Canadian Journal of Physiology and Pharmacology
language:en
Short-container-title:Can. J. Physiol. Pharmacol.

Author:

Maeda Toyoki¹²³,Sakoda Saburo¹²³,Suzuki Tomokazu¹²³,Makino Naoki¹²³

Affiliation:

1. Division of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Oita 874-0838, Japan.

2. Department of Neurology, Osaka University, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.

3. Division of Molecular and Clinical Genetics, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, 4546, Tsurumihara, Beppu, Oita 874-0838, Japan.

Abstract

Possible somatic DNA recombination in the brain has been investigated by attempting to capture direct or indirect evidence of it. Until recently, the biological significance of the DNA event, the genes is involved in the recombination, or even whether the event actually occurs in the brain has remained unclear. The DNA-rearranged locus-oriented approach and the recombination activity-oriented approach have mutually contributed to the elucidation of the biological features of extra-immune system somatic DNA recombination. There have been only 2 loci proposed for the candidate, one is a repetitive sequence and the other DNA recombination is nonrepetitive locus. This review states conventional concepts and discussions chronologically and finally to the newest aspects of DNA rearrangement in the brain.

Publisher

Canadian Science Publishing

Subject

Physiology (medical),Pharmacology,General Medicine,Physiology

Link

http://www.nrcresearchpress.com/doi/pdf/10.1139/y05-099

Reference36 articles.

1. On Somatic Recombination in the Central Nervous System of Transgenic Mice

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