Effect of adrenal denervation on the glucose, insulin, and glucagon responses to exercise in sheep

Author:

Brockman Ronald P.

Abstract

Previous studies suggest that adrenal catecholamines mediate, in part, the glucose and pancreatic hormonal responses to exercise in sheep. This was examined in sheep whose adrenals were denervated to prevent stress-induced changes in catecholamine secretion. The innervation to the right adrenal gland was severed and the left adrenal was removed. Adrenal denervation was associated with a reduction in exercise-induced hyperglycemia and impairment, as measured by [2-3H]glucose, of the increase in glucose appearance during the first 10 min of exercise and increased metabolic clearance rate of glucose after 20 min of exercise. Insulin concentrations were significantly higher during exercise after adrenal denervation than in the controls. Adrenal denervation did not alter the rise in glucagon due to exercise. These effects are consistent with adrenomedullary hormonal stimulation of hepatic and muscular glycogenolysis, either directly or indirectly through the regulation of insulin secretion during exercise in sheep.

Publisher

Canadian Science Publishing

Subject

Physiology (medical),Pharmacology,General Medicine,Physiology

Cited by 15 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Simultaneous evaluation of medullary secretory functions of normal and acutely denervated adrenals;American Journal of Physiology-Regulatory, Integrative and Comparative Physiology;1991-02-01

2. Effects of glucagon and α- and β-agonists on glycogenolysis and gluconeogenesis in isolated ovine hepatocytes;Biochimica et Biophysica Acta (BBA) - Molecular Cell Research;1990-04

3. Effects of obesity on insulin sensitivity and responsiveness in sheep;American Journal of Physiology-Endocrinology and Metabolism;1989-11-01

4. Effect of Exercise Training on Insulin and Glucagon Release from Perfused Rat Pancreas;Hormone and Metabolic Research;1987-09

5. Key hormonal and metabolic control systems modifying nutrient use;Proceedings of the Nutrition Society;1986-07

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