Inhibition of influenza A virus hemagglutinin and induction of interferon by synthetic sialylated glycoconjugates

Abstract

Multivalent forms of neoglycoproteins and polyacrylamides containing sialic acid were prepared and shown to be potent inhibitors of influenza A virus (H3N2) hemagglutinin with chick red blood cells. The synthetic sialylated glycoconjugates, although they were neuraminidase substrates, did not suppress viral neuraminidase and did not reduce infectivities in chick embryos. The copolyacrylamide conjugate containing a spacer group of ~11 Å (1 Å = 0.1 nm) between the polymer backbone and the sialic acid residues was the best hemagglutinin inhibitor. Moreover, it exhibited promising interferon-inducing properties. Key words: Influenza A virus, sialic acid, inhibitor, hemagglutinin, interferon.