Author:
Ogilvie Kelvin K.,Nguyen-Ba Nghe,Hamilton Raymond G.
Abstract
An acyclonucleoside structure (Z) has been developed which possesses three hydroxymethyl groups attached to the carbon which is analogous to the 4′-carbon of natural nucleosides. The presence of the third hydroxymethyl group significantly reduces activity against herpesviruses as compared to the dihydroxymethyl (BIOLF-62) and monohydroxymethyl (acyclovir) models.
Publisher
Canadian Science Publishing
Subject
Organic Chemistry,General Chemistry,Catalysis
Cited by
41 articles.
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