Synthesis and nuclear magnetic resonance spectra of platinum compounds with thiourea derivatives

Abstract

Compounds of the type trans-[PtL2T2]Cl2 where L = NH3, methylamine, dimethylamine, pyridine, and 2-aminopyrimidine and T = N-methylthiourea and N,N′-dimethylthiourea and where L = NH3 and T = N,N,N′,N′-tetramethylthiourea have been synthesized. The 1H nmr spectra have shown that the thiourea derivatives are bonded to platinum by the sulfur atom. The methyl protons of N-methylthiourea and one methyl group protons of N,N′-dimethylthiourea in the complexes, where L is aromatic, showed resonance at higher field after coordination to the metal. This was explained by an intramolecular interaction between the methyl group and the aromatic ring. The nmr spectra of the [PtT4]Cl2 compounds were also measured.