Synthèse et étude du rearrangement des diazoles-1,3: alkyl-1 alkylthio-2 (allylthio, arylthio, cycloalkylthio) imidazoles. Partie I. Synthèse et études physicochimiques

Abstract

The synthesis and the [Formula: see text] rearrangement of thioethers in the N- and S-substituted imidazolic series have been studied (60 compounds). The physicochemical studies of the thioethers and mercapto compounds, catalysts of the rearrangement, and of the eventual hydrolysis products have been carried out and the kinetics of rearrangement have been examined at several temperatures. The rearrangement and hydrolysis results are compared with those of 1-alkyl-2-methylthio-Δ-2-imidazolines and 1-alkyl-2-methylthio-Δ-2-tetrahydropyrimidines and the electronic and steric effects are discussed. In this first part the synthetic aspect and physicochemicals results are presented.