THE EFFECT OF NECROGENIC DIETS ON THE ACTIVITIES OF CERTAIN ENZYME SYSTEMS IN THE RED BLOOD CELLS OF RATS

Abstract

The enzymic activities of glucose-6-phosphate dehydrogenase, glutathione reductase, and catalase were studied in the red blood cells of male rats which were fed a basal diet designed to induce acute hepatic necrosis. Significant decreases in the activity were found for all three systems. These changes were prevented by supplementing the basal diet with one of the following: methionine, sodium selenite, DL-α-tocopherol acetate, or all three factors plus cystine.There was no significant change in 6-phosphogluconic dehydrogenase activity when it was investigated under similar circumstances.