Author:
Carlo Frederick J. Di,Meli Albert,Haynes Lloyd J.,Honrath William L.,Lucker William F.,Sliver Nancy J.
Abstract
Splenectomized as well as intact mice responded to the injection of live Mycobacterium phlei Halpern with bimodal reticuloendothelial hyperfunction as measured by the intravascular clearance of colloidal carbon. The first stimulation persisted longer in splenectomized mice and the second stimulation endured longer in intact mice. Liver hyperplasia and lung inflammation were more severe after splenectomy, and made evident the manner in which the operated mice attempted to compensate for the extirpated organ. The phagocytic indices and histological findings indicate that the spleen suppresses the phagocytic activity of the liver and protects it from pathological change.
Publisher
Canadian Science Publishing