The combination of single nucleotide polymorphisms rs6720173 (ABCG5), rs3808607 (CYP7A1), and rs760241 (DHCR7) is associated with differing serum cholesterol responses to dairy consumption-Reference-Cited by-同舟云学术

The combination of single nucleotide polymorphisms rs6720173 (ABCG5), rs3808607 (CYP7A1), and rs760241 (DHCR7) is associated with differing serum cholesterol responses to dairy consumption

Published:2018-10 Issue:10 Volume:43 Page:1090-1093
ISSN:1715-5312
Container-title:Applied Physiology, Nutrition, and Metabolism
language:en
Short-container-title:Appl. Physiol. Nutr. Metab.

Author:

Abdullah Mohammad M.H.¹²,Eck Peter K.¹²,Couture Patrick³,Lamarche Benoît³,Jones Peter J.H.¹²

Affiliation:

1. Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.

2. Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, MB R3T 6C5, Canada.

3. Institute of Nutrition and Functional Foods, Laval University, Québec City, QC G1V 0A6, Canada.

Abstract

Existing evidence on the influence of genetic architecture on serum cholesterol responsiveness to dietary interventions focuses on individual single nucleotide polymorphisms and single nutrients. We associated the combination of ABCG5 rs6720173-C, CYP7A1 rs3808607-TT, and DHCR7 rs760241-GG genotypes with lower low-density lipoprotein cholesterol concentrations relative to the combination of rs6720173-GG, rs3808607-G, and rs760241-A genotypes (–0.37 ± 0.12 (n = 9) vs. +0.38 ± 0.14 mmol/L (n = 7), p = 0.0016) following a blended dairy (3 servings/day for 4 weeks) intervention.

Publisher

Canadian Science Publishing

Subject

Physiology (medical),Nutrition and Dietetics,Physiology,General Medicine,Endocrinology, Diabetes and Metabolism

Link

http://www.nrcresearchpress.com/doi/pdf/10.1139/apnm-2018-0085

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