Effects of an acute bout of resistance exercise on fiber-type specific GLUT4 and IGF-1R expression

Author:

Gallagher Philip M.1,Touchberry Chad D.2,Teson Kelli1,McCabe Everlee1,Tehel Michelle1,Wacker Michael J.2

Affiliation:

1. Department of Health, Sport, and Exercise Sciences, University of Kansas, Lawrence, KS 66045, USA.

2. Department of Basic Medical Science, University of Missouri-Kansas City, School of Medicine, Kansas City, MO 64108, USA.

Abstract

The effects of resistance exercise on fiber-type–specific expression of insulin-like growth factor I receptor (IGF-1R) and glucose transporter 4 (GLUT4) was determined in 6 healthy males. The expression of both genes increased in Type I fibers (p < 0.05), but only GLUT4 increased (p < 0.05) in Type II fibers. These data demonstrates that an acute bout of resistance exercise can up-regulate mechanisms of glucose uptake in slow and fast-twitch fibers, but the IGF signaling axis may not be as effective in fast-twitch fibers.

Publisher

Canadian Science Publishing

Subject

Physiology (medical),Nutrition and Dietetics,Physiology,General Medicine,Endocrinology, Diabetes and Metabolism

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