Inhibition of Akt2 phosphorylation abolishes the calorie restriction-induced improvement in insulin-stimulated glucose uptake by rat soleus muscle-Reference-Cited by-同舟云学术

Inhibition of Akt2 phosphorylation abolishes the calorie restriction-induced improvement in insulin-stimulated glucose uptake by rat soleus muscle

Published:2016-11 Issue:11 Volume:41 Page:1208-1211
ISSN:1715-5312
Container-title:Applied Physiology, Nutrition, and Metabolism
language:en
Short-container-title:Appl. Physiol. Nutr. Metab.

Author:

Sharma Naveen¹²,Arias Edward B.¹,Cartee Gregory D.¹³⁴

Affiliation:

1. Muscle Biology Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA.

2. School of Health Sciences, Central Michigan University, Mount Pleasant, MI 48859, USA.

3. Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.

4. Institute of Gerontology, University of Michigan, Ann Arbor, MI 48109, USA.

Abstract

Calorie restriction (CR; ∼60%–65% of ad libitum consumption) can enhance insulin-stimulated glucose uptake (ISGU) in predominantly slow-twitch skeletal muscles (e.g., soleus) by an incompletely understood mechanism. We used an Akt inhibitor (MK-2206) to eliminate CR’s effect on insulin-stimulated Akt2 phosphorylation in isolated rat soleus muscles. We found long-term CR-enhanced ISGU was abolished by eliminating the CR effect on Akt2 phosphorylation, suggesting the CR-induced benefit on ISGU in the predominantly slow-twitch soleus relies on enhanced Akt2 phosphorylation.

Publisher

Canadian Science Publishing

Subject

Physiology (medical),Nutrition and Dietetics,Physiology,General Medicine,Endocrinology, Diabetes and Metabolism

Link

http://www.nrcresearchpress.com/doi/pdf/10.1139/apnm-2016-0326

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