Low-intensity resistance training with partial blood flow restriction and high-intensity resistance training induce similar changes in skeletal muscle transcriptome in elderly humans-Reference-Cited by-同舟云学术

Low-intensity resistance training with partial blood flow restriction and high-intensity resistance training induce similar changes in skeletal muscle transcriptome in elderly humans

Published:2019-02 Issue:2 Volume:44 Page:216-220
ISSN:1715-5312
Container-title:Applied Physiology, Nutrition, and Metabolism
language:en
Short-container-title:Appl. Physiol. Nutr. Metab.

Author:

Vechin Felipe C.¹,Libardi Cleiton A.²,Conceição Miguel S.¹,Damas Felipe¹,Cavaglieri Claudia R.³,Chacon-Mikahil Mara Patricia T.³,Coutinho Luiz L.⁴,Andrade Sonia C.S.⁴⁵,Neves Jr Manoel T.⁶,Roschel Hamilton¹,Tricoli Valmor¹,Baptista Igor L.⁷,Moriscot Anselmo A.⁷,Ugrinowitsch Carlos¹

Affiliation:

1. School of Physical Education and Sport, University of São Paulo, São Paulo, São Paulo 05508-030, Brazil.

2. Laboratory of Neuromuscular Adaptations to Resistance Training, Department of Physical Education, Federal University of São Carlos, São Carlos, São Paulo 13565-905, Brazil.

3. Faculty of Physical Education, State University of Campinas, Campinas, São Paulo 13083-851, Brazil.

4. University of São Paulo (USP)/Luiz de Queiroz College of Agriculture (ESALQ), Piracicaba, São Paulo 13418-900, Brazil.

5. Department of Genetics and Evolutionary Biology-IB, University of São Paulo, São Paulo, SP 05508-090, Brazil.

6. School of Medicine, University of São Paulo, São Paulo 01246-903, Brazil.

7. Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.

Abstract

We aimed to investigate the mechanisms underlying muscle growth after 12 weeks of resistance training performed with blood flow restriction (RT–BFR) and high-intensity resistance training (HRT) in older individuals. Participants were allocated into the following groups: HRT, RT–BFR, or a control group. High-throughput transcriptome sequencing was performed by the Illumina HiSeq 2500 platform. HRT and RT–BFR presented similar increases in the quadriceps femoris cross-sectional area, and few genes were differently expressed between interventions. The small differences in gene expression between interventions suggest that similar mechanisms may underpin training-induced muscle growth.

Publisher

Canadian Science Publishing

Subject

Physiology (medical),Nutrition and Dietetics,Physiology,General Medicine,Endocrinology, Diabetes and Metabolism

Link

http://www.nrcresearchpress.com/doi/pdf/10.1139/apnm-2018-0146

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