A new efficient synthesis of α-methyl-β-ketoesters through an Eschenmoser sulfide reaction

Abstract

Various α-methyl-β-ketoesters were readily synthesized through Eschenmoser condensation of thioamides with a commercially available bromoester. β-Enaminoesters were easily prepared through this sulfide contraction reaction and were hydrolysed to afford the corresponding β-ketoesters in moderate to good yields.Key words: α-alkylated-β-ketoesters, Eschenmoser, β-enaminoesters.