Author:
Menard Marcel,Rivest Pierre,Belleau Bernard,Daris Jean-Paul,Perron Yvon G.
Abstract
The synthesis of morphinans incorporating a hydroxyl group at position 14 as well as an appropriate alkyl substitution in ring C is described. It is shown that the spatial area around ring C plays an important role at the analgesic receptor level. A novel morphine structure with ring C frozen in a boat conformation is also described.
Publisher
Canadian Science Publishing
Subject
Organic Chemistry,General Chemistry,Catalysis
Cited by
5 articles.
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