Increased axonal excitability during exposure to hyperbaric oxygen

Abstract

The effect of high oxygen pressure on neural function was studied in the isolated nervous system of the cockroach. Intracellular and extracellular action potentials were recorded from single giant axons during exposure to 7 ATA (atmosphere absolute) (1 ATA = 0.1 MPa) of oxygen. Axonal excitability was measured as changes in stimulus strength–duration relationship. Initially, a transient increase in the rheobase current was observed followed by a significant decline to 75% of air control values. This decrease was accompanied by a parallel increase in the membrane time constant. The results demonstrate that hyperbaric oxygen increases axonal excitability. Such changes are consistent with the epileptogenic properties of high oxygen pressure.