Some factors influencing the toxicity of thrombolytic enzymes (Brinase)

Abstract

A heterogenous dog population was subjected to standardized systemic administration of the fibrinolytic enzyme Brinase. The extent of toxicity (hypocoagulable blood, hypotension, hemoconcentration) depended primarily on the degree and speed of inhibitor neutralization and the eventual appearance of free proteolysis. Administration of an "optimal" (i.e. thrombolytic yet not proteolytic) dosage elicited occasional unexpected hypotensive responses owing to variations in body condition of individual dogs and variations in the rate and duration of drug infusion.