Author:
Mochizuki Mariko,Ueda Fukiko,Sano Tadashi,Hondo Ryo
Abstract
Vanadate has been known to induce a transient increase in high K+induced contraction, and also gradually relax the high K+contraction itself in guinea pig taenia coli. The relationship between the rate of relaxation and ion content of Na+, K+, and V ion at the cellular level was investigated when vanadate was applied to contracted muscle. Tissue Na+and V ion content increased linearly, depending on the time after vanadate treatment, reaching maximum levels of approximately 50 mM·kg-1and 0.25 mM·kg-1wet weight, respectively. There was a positive correlation between the V ion and Na+contents, while there was a negative correlattion between both ions and the relaxed rate of the high K+induced contraction. The uptake of V ion was affected by the external K+concentration, and the maximum rate of V ion uptake decreased to 40% in the presence of 90 mM external K+. These results suggest that a small amount of V ion was enough to inhibit the Na+pump activity and muscle contraction in the high K+solution.Key words: vanadate, high K+, relaxation, taenia coli, vanadium.
Publisher
Canadian Science Publishing
Subject
Physiology (medical),Pharmacology,General Medicine,Physiology
Cited by
2 articles.
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