The Effects In Vivo of L- and D-para-Chlorophenylalanine on the Aromatic Hydroxylating Activity of Rat Liver

Abstract

Injections of D- or L-p-chlorophenylalanine into rats resulted in identical decreases in the phenylalanine hydroxylase activities of their livers. Similar effects were produced on the ability of the livers to convert L-m-tyrosine to 3,4-dihydroxyphenylalanine. No effects on the tyrosine hydroxylase activities of the brain and adrenals could be detected.