Radiation-induced binding of 2,2,6,6-tetramethyl-1,4-piperidone-N-oxyl to thymidine in oxygen-free aqueous solutions. Isolation and characterization of the adducts

Abstract

Steady-state γ-radiolysis of deaerated aqueous solutions of thymidine has been carried out in the presence of 2,2,6,6-tetramethyl-1,4-piperidone-N-oxyl (TAN), a well-known radiosensitizing agent. The eight main radiation-induced TAN addition products to thymidine have been isolated and characterized by 1H and 13C nmr, cd, and fast-atom bombardment mass spectrometry measurements.