The Effect of Oral Oxyphenbutazone (Tandearil) on Tumor Growth and the Level of the Seromucoid Fraction in Rats Bearing Walker 256 Carcinoma

Abstract

The effect of the oral administration of oxyphenbutazone (Tandearil) on tumor growth and the levels of the seromucoid protein and seromucoid-bound carbohydrates of rats bearing Walker 256 has been studied. Oxyphenbutazone was administered at two dose levels, namely 60 mg/kg per day and 100 mg/kg per day. The anticipated elevation of seromucoid protein and seromucoid-bound carbohydrates was observed in untreated tumor-bearing rats. Oxyphenbutazone treatment suppressed the initial response of seromucoid protein and seromucoid-bound carbohydrate in tumor-bearing rats such that no significant elevation occurred over levels recorded for untreated nontumor-bearing rats for the first 8 days following transplantation. After 8 days the levels of seromucoid protein and seromucoid-bound carbohydrate were elevated in treated tumor-bearing animals as compared with untreated nontumor-bearing controls although the magnitude of the elevation was significantly less than that observed in untreated tumor-bearing animals.Oxyphenbutazone at an oral dose of 100 mg/kg per day proved toxic to the adult male rat. Toxicity was manifested by weight loss and occasionally by a fatal hemorrhagic gastritis.Tumors regressed in oxyphenbutazone-treated animals, and survival times of animals treated with oxyphenbutazone at 60 mg/kg per day exceeded those of comparable untreated tumor-bearing animals. In addition, treated animals were free of apparent malignant disease at the completion of the study.