Overexpression of the CXCL3 gene in response to oxidized low-density lipoprotein is associated with the presence of tendon xanthomas in familial hypercholesterolemia

Author:

Martín-Fuentes Paula1,Civeira Fernando1,Solanas-Barca María1,García-Otín Angel Luis1,Jarauta Estíbaliz1,Cenarro Ana1

Affiliation:

1. Laboratorio de Investigación Molecular, Hospital Universitario Miguel Servet, Instituto Aragonés de Ciencias de la Salud (I+CS), Edificio de Consultas Externas, planta 4ª, Zaragoza 50009, Spain.

Abstract

To examine if overexpression of certain chemokines and proinflammatory cytokines in response to oxidized low-density lipoprotein could be involved in the onset and development of tendon xanthomas (TX), we quantified IL-1β, TNF-α, and IL-8 and compared gene expression of PPAR-γ, NF-κBIA, IL-8, IL-1β, CXCL3, tryptase, and TNF-α in macrophages of familial hypercholesterolemia subjects with and without TX stimulated with oxidized low-density lipoprotein at 1, 3, 6, and 18 h of incubation. We propose that chemokines belonging to the CXC family could play an important role in the etiology of TX, with CXCL3 being a possible biological marker of onset and development of TX.

Publisher

Canadian Science Publishing

Subject

Cell Biology,Molecular Biology,Biochemistry

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