Effect of streptomycin on the phosphorus metabolism of Bacillus subtilis

Abstract

Streptomycin at a dose causing decrease of growth of Bacillus subtilis strain B3 greatly affected the use of phosphorus compounds from the medium during the exponential phase of growth of the organism. Streptomycin also interfered with the accumulation of phosphate esters in the cells of B. subtilis. The accumulation of phosphate esters like fructose-6-phosphate, fructose-1,6-diphosphate, triose phosphates, phosphoglyceric acid, and phosphopyruvic acid was consistently lower in the streptomycin-treated culture throughout the entire period of cellular growth.