Total synthesis of 3,17β-dihydroxy-6-oxaestra-1,3,5(10),7-tetraen and related miroestrol analogues

Author:

Findlay John A.,Mebe Paul,Stern Michael D.,Givner M. L.

Abstract

3,17β-Dihydroxy-6-oxaestra-1,3,5(10),7-tetraen and related steroidal compounds have been synthesized in high yield via condensation of 7-methoxy-4-vinyl coumarin and 2-methyl-1,3-pentanedione. The approximate uterotrophic activity of the synthetic compounds relative to 17β-estradiol has been determined.

Publisher

Canadian Science Publishing

Subject

Organic Chemistry,General Chemistry,Catalysis

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