THE EFFECT OF TOLBUTAMIDE (RASTINON) ON THE LEVELS OF GLUCOSE AND INORGANIC PHOSPHORUS OF BLOOD IN NORMOTHERMIC AND HYPOTHERMIC RATS

Abstract

Blood sugar, inorganic phosphorus, and hematocrit values were measured in normothermic and hypothermic (25 °C) fasted rats injected intra-arterially with tolbutamide (Rastinon) and a control solution. Doses of 12.5, 25, 50, and 100 mg/kg body weight of tolbutamide led to hypoglycemia in the normothermic rats, whereas doses of 25 and 200 mg/kg tolbutamide had no effect on the blood sugar levels of hypothermic rats. Doses of 25, 50, 100, and 200 mg/kg caused the blood inorganic phosphorus levels to fall, and in the so-called "normothermic" rats the colonic temperature was reduced. A dose of 200 mg/kg injected intra-arterially led to a fall in the inorganic phosphorus levels of blood in hypothermic rats.