Cholesterol Metabolism and Vitamin B6. III. The Stimulation of Hepatic Cholesterogenesis in the Vitamin B6-Deficient Rat

Abstract

The rate of incorporation of labeled acetate into cholesterol by liver slices of pyridoxine-deficient rats was found to be three times that of control rats; with liver homogenates the difference between the two groups was even greater. Using the CO2 trapping technique, a 30% decrease in the hepatic acetate pool size was observed in pyridoxine-deficient rats and a 20% increase in pair-fed rats. Activity of the Krebs cycle was decreased by a third in the pair-fed rats.