Author:
Friedman Sydney M.,Gustafson Brigid,Hamilton Dorothy
Abstract
The separate effects of aldosterone, vasopressin, and corticosterone on salt and water distribution were examined in the neurohypophysectomized adrenalectomized rat with conventional partition methods for plasma and skeletal muscle. In the absence of countering hormones, even small amounts of aldosterone suffice to produce a gain in muscle sodium. This is usually associated with some degree of potassium loss and a tendency for the extracellular space to expand at the expense of cell water. Small doses of vasopressin, when not hormonaily opposed, suffice to produce a loss of muscle sodium, usually associated with a tendency for the extracellular space to contract in favor of an increase in cell water. Corticosterone, when not hormonally countered, produces effects similar to those of vasopressin and acts as a desalting agent.
Publisher
Canadian Science Publishing
Subject
Physiology (medical),Pharmacology,General Medicine,Physiology
Cited by
6 articles.
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