Phosphorus ligand-free Suzuki–Miyaura reactions in the presence of ABTS at room temperature in water

Abstract

A catalytic system for a phosphorus ligand-free Suzuki–Miyaura reaction in water at room temperature was disclosed. Ammonium 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonate) (ABTS) was an efficient promoter and acted both as a ligand and as a surfactant for the synthesis of biaryl compounds via the Suzuki–Miyaura reaction in water. The targeted biaryl architectures were achieved under mild conditions with high efficiency and good functional group tolerance.