OXIME MIXTURES AND ATROPINE IN THE PROTECTION OF MICE AND RATS FROM SARIN POISONING-Reference-Cited by-同舟云学术

OXIME MIXTURES AND ATROPINE IN THE PROTECTION OF MICE AND RATS FROM SARIN POISONING

Published:1960-01-01 Issue:1 Volume:38 Page:1035-1043
ISSN:0576-5544
Container-title:Canadian Journal of Biochemistry and Physiology
language:en
Short-container-title:Can. J. Biochem. Physiol.

Author:

Coleman I. W.¹,Little P. E.¹,Grant G. A.¹

Affiliation:

1. Defence Research Kingston Laboratory, Kingston, Ontario, of the Defence Research Board of Canada

Abstract

The protection provided by oral administration of mixtures of oximes prophylactically in conjunction with intramuscular atropine given therapeutically against sarin poisoning in the rat and mouse is reported. N-Methylpyridinium-2-aldoxime methane sulphonate (P-2-S) in combination with diacetylmonoxime (DAM) demonstrated a synergistic action in protecting rats from sarin which raised the protection to double the value obtained from DAM alone. A similar synergism was found for P-2-S and monoisonitrosoacetone in the rat. This combination raised the protection obtainable from either partner by a factor of 8. Both oxime mixtures were less effective in the mouse than in the rat.

Publisher

Canadian Science Publishing

Subject

General Medicine

Link

http://www.nrcresearchpress.com/doi/pdf/10.1139/y60-129

Reference25 articles.

1. USES AND HAZARDS OF THE ORGANIC PHOSPHATE ANTICHOLINESTERASE COMPOUNDS

2. The effects and treatment of nerve gas poisoning

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1. Disposition and metabolism of acetylcholinesterase reactivators 2PAM-I, TMB4 and R665 in rats submitted to organophosphate poisoning;Xenobiotica;1991-01

2. Disposition and metabolism of two acetylcholinesterase reactivators, pyrimidoxime and HI6, in rats submitted to organophosphate poisoning;Xenobiotica;1990-01

3. Oximes Antagonistic to Inhibitors of Cholinesterase;Journal of Pharmaceutical Sciences;1964-10