Abstract
The pulmonary inactivation of lys-8 vasopressin in anesthetized, normal dogs, cats, rabbits, and rats, and that of Pitressin in rats, was studied by means of the systemic pressure response technique. The pulmonary fate of oxytocin was measured in rats by the same technique and, in addition, by means of an in vivo oxytocic assay. The pulmonary inactivation of these three neurohypophyseal peptides was negligible in all instances. The data reinforce the concept that circulating hormones freely cross the pulmonary vascular bed.
Publisher
Canadian Science Publishing
Subject
Physiology (medical),Pharmacology,General Medicine,Physiology
Cited by
10 articles.
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