1,2,6-Thiadiazin-3,5(2H,6H)-dione 1,1-dioxide derivatives: crystal structure, physico-chemical and biological properties-Reference-Cited by-同舟云学术

1,2,6-Thiadiazin-3,5(2H,6H)-dione 1,1-dioxide derivatives: crystal structure, physico-chemical and biological properties

Published:1987-02-01 Issue:2 Volume:65 Page:298-302
ISSN:0008-4042
Container-title:Canadian Journal of Chemistry
language:en
Short-container-title:Can. J. Chem.

Author:

Goya Pilar,Nieves Rosa,Ochoa Carmen,Rodellas Carmen,Martinez-Ripoll Martín,García-Blanco Severino

Abstract

Crystal structure, 1H and 13C nmr spectroscopy and pKa measurements of 1,2,6-thiadiazin-3,5(2H,6H)-dione derivatives related with phenylbutazone are reported. An anomalous variation in the pKa values of compounds 1,2, and 3 has been observed. Antiinflammatory, analgesic, and antipyretic activities of these compounds have been evaluated.

Publisher

Canadian Science Publishing

Subject

Organic Chemistry,General Chemistry,Catalysis

Link

http://www.nrcresearchpress.com/doi/pdf/10.1139/v87-049

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