Neutralizing response of rabbits to an experimental rubella subunit vaccine made from immunostimulating complexes
-
Published:1988-12-01
Issue:12
Volume:34
Page:1351-1354
-
ISSN:0008-4166
-
Container-title:Canadian Journal of Microbiology
-
language:en
-
Short-container-title:Can. J. Microbiol.
Author:
Trudel Michel,Nadon Francine,Séguin Cécile,Payment Pierre
Abstract
The purpose of this study was to evaluate experimentally the immunogenicity in rabbits of rubella subunits adsorbed to the adjuvant Quil A. The adsorbed viral proteins form structurally defined ImmunoStimulating COMplexes (ISCOMs). Rubella ISCOMs were tested for their capacity to induce neutralizing and hemagglutination-inhibiting antibodies, in comparison with a commercial live attenuated vaccine. Rubella ISCOMs were as efficient as the live vaccine in inducing neutralizing and hemagglutination inhibiting antibodies, suggesting the possibility of developing an ISCOMs subunit vaccine.
Publisher
Canadian Science Publishing
Subject
Genetics,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Immunology,Microbiology
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Advanced nanoscale delivery systems for mRNA-based vaccines;Biochimica et Biophysica Acta (BBA) - General Subjects;2024-03
2. Rubella Vaccines;Plotkin's Vaccines;2023
3. Rubella Vaccines;Plotkin's Vaccines;2018
4. Rubella vaccine;Vaccines;2013
5. Rubella vaccine;Vaccines;2008