Deoxy-cytochalasins from a marine-derived fungus Spicaria elegans-Reference-Cited by-同舟云学术

Deoxy-cytochalasins from a marine-derived fungus Spicaria elegans

Published:2009-03 Issue:3 Volume:87 Page:486-489
ISSN:0008-4042
Container-title:Canadian Journal of Chemistry
language:en
Short-container-title:Can. J. Chem.

Author:

Lin Zhen-Jian¹,Zhu Tian-Jiao¹,Zhang Guo-Jian¹,Wei Hong-Juan¹,Gu Qian-Qun¹

Affiliation:

1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, PR China.

Abstract

Treatment of Spicaria elegans with cytochrome P-450 inhibitor resulted in two new deoxy-cytochalasins, 7-deoxy-cytochalasin Z7 (1) and 7-deoxy-cytochalasin Z9 (2), which were recognized as plausible precursors of cytochalasins Z7 and Z9, respectively. Their structures were elucidated by spectroscopic methods and the absolute configuration of 1 was determined by the conventional Mosher ester method. Their cytotoxicities against two cancer cell lines were evaluated.

Publisher

Canadian Science Publishing

Subject

Organic Chemistry,General Chemistry,Catalysis

Link

http://www.nrcresearchpress.com/doi/pdf/10.1139/V09-006

Reference7 articles.

1. 10-Phenyl-[12]-cytochalasins Z7, Z8, and Z9 from the Marine-Derived Fungus Spicaria elegans

2. Novel Open-Chain Cytochalsins from the Marine-Derived Fungus Spicaria elegans

3. Molecular Basis of Cytochalasan Biosynthesis in Fungi: Gene Cluster Analysis and Evidence for the Involvement of a PKS-NRPS Hybrid Synthase by RNA Silencing

4. Useful approach to find the plausible biosynthetic precursors of secondary metabolites using P-450 inhibitors: postulated intermediates of chaetoglobosin A

5. RKS-1778, a New Mammalian Cell-Cycle Inhibitor and a Key Intermediate of the [11]Cytochalasin Group

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