THE EFFECT OF OXYPHENBUTAZONE (TANDEARIL) ON THE LEVEL OF THE SEROMUCOID FRACTION OF RATS BEARING WALKER 256 CARCINOMA

Abstract

The effect of oxyphenbutazone (Tandearil) on the seromucoid protein and seromucoid-bound carbohydrates of Walker 256 carcinoma bearing rats has been investigated. Initially, treatment is associated with increased tumor growth and suppression of the anticipated glycoprotein response in the serum. After the eighth day, tumor growth ceases in treated animals and the serum glycoproteins manifest progressive elevations which are, however, less than those observed in untreated tumor-bearing controls. The survival time of treated animals exceeded that of untreated tumor-bearing animals, and treated animals were free of gross malignant disease at the time of death.