A novel and green version of the Passerini reaction in an ionic liquid ([bmim][BF4])

Abstract

The Passerini three-component condensation among a carboxylic acid (1), an aldehyde or ketone (2), and an isocyanide (3) was carried out for the first time in an ionic liquid, [bmim][BF4], and a series of acyloxycarboxamides were obtained through this reaction. The method presented herein has the advantages of high efficiency, a greener nature, and a simple operational procedure. Moreover, the ionic liquid can be easily recovered and reused for several runs without obvious loss of efficiency.Key words: Passerini reaction, acyloxycarboxamides, ionic liquid, green synthesis.