Facilitated diffusion of monosaccharides in smooth muscle of rat vas deferens in vitro
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Published:1984-09-01
Issue:9
Volume:62
Page:1112-1115
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ISSN:0008-4212
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Container-title:Canadian Journal of Physiology and Pharmacology
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language:en
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Short-container-title:Can. J. Physiol. Pharmacol.
Abstract
The suitability of rat vas deferens for investigating sugar transport in smooth muscle was determined in vitro, with the nonmetabolized glucose analog 3-O-methyl-D-glucose as test sugar. Vas deferens smooth muscle contains a facilitated diffusion system for monosaccharides, as shown by saturation of the transport sites and by competition between 3-O-methyl-D-glucose and D-glucose. The activity of the facilitated diffusion system could be enhanced by hyperosmolarity and by contractile activity, but frequency dependency could not be established. A high concentration of insulin (100 mU/mL) was required to stimulate sugar transport. As smooth muscle is not a primary tissue for the storage of energy reserves, it does not require large numbers of insulin receptors.
Publisher
Canadian Science Publishing
Subject
Physiology (medical),Pharmacology,General Medicine,Physiology
Cited by
1 articles.
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