Author:
Shephard Roy J,Shek Pang N
Abstract
The influence of cold exposure on immune function is reviewed. Data obtained mainly on small mammals suggest that the acute effect of severe chilling is a suppression of several cellular and humoral components of the immune response, including a decrease of lymphocyte proliferation, a down-regulation of the immune cascade, a reduction of natural killer (NK) cell count, cytolytic activity, activation of complement, and the induction of heat shock proteins. However, adaptation to a given cold stimulus appears to develop over the course of 2-3 weeks. Further work is needed to examine interactions between cold exposure and exercise, and to determine whether the disturbances of immune response are sufficient to impair immunosurveillance in human subjects.Key words: cytolic activity, heat shock proteins, hypothermia, infection, leukocytes.
Publisher
Canadian Science Publishing
Subject
Physiology (medical),Pharmacology,General Medicine,Physiology
Cited by
77 articles.
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