Acute phase nematode infection reduces resting metabolic rate in both protein-sufficient and protein-deficient mice

Abstract

The objective of this study was to investigate whether protein deficiency concurrent with the acute phase of infection with the murine nematode Heligmosomoides bakeri (Durette-Desset, Kinsella and Forrester, 1972; Tenora and Barus, 2001) affected the resting metabolic rate (RMR) in BALB/c mice, and whether deworming caused RMR to return to normal. Mice fed either a protein-sufficient (PS, 24%) or protein-deficient (PD, 3%) diet were infected with 100 larvae, and then treated with an anthelmintic drug on 9 and 14 days postinfection (dpi). RMR was measured on –2, 2, 7, and 19 dpi. The results showed that protein deficiency did not affect RMR at any of these times. RMR was unchanged immediately following infection (2 vs. –2 dpi) at the time when larvae are first embedded in the serosal musculture. Surprisingly, at 7 dpi when larvae migrate from the serosal musculture into the intestinal lumen, RMR was significantly lower in both diet groups compared with earlier time points. This reduced RMR persisted even after deworming. Possible reasons for these results are discussed.