Glucose oxidation in fresh guinea pig cornea
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Published:1979-10-01
Issue:10
Volume:57
Page:1174-1177
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ISSN:0008-4212
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Container-title:Canadian Journal of Physiology and Pharmacology
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language:en
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Short-container-title:Can. J. Physiol. Pharmacol.
Author:
Liao Horng-Miao R.,Lin Boniface J.,Hasany Syed M.,Basu Prasanta K.
Abstract
The rate of glucose oxidation of fresh corneas of guinea pigs at different ages has been determined.Full-thickness corneal discs, 4 mm in diameter, were incubated in radioactive glucose solution. The quantity of the released CO2 was expressed in terms of the corneal discs, their dry weights, and DNA and protein contents. The rate of glucose metabolized to CO2 per hour was about 300 pmol/μg DNA for guinea pigs weighing approximately 800 g. Glucose oxidation decreased as the age of the animals increased.Our results compared well with those obtained in other species. We therefore feel that the guinea pig should be a suitable model for research on the metabolism of corneas.
Publisher
Canadian Science Publishing
Subject
Physiology (medical),Pharmacology,General Medicine,Physiology