Author:
Yeung D. L.,Veen-Baigent M. J.
Abstract
Urinary and fecal excretion of 3H-labelled metabolites of vitamin A was followed in rats given a single oral dose of 3H-11,12-retinyl acetate (RA), followed 8 days later by a dose of non-labelled RA. The level of radioactivity in urine and feces fell to a more consistently lower level by the 8th day after administration of 3H-RA but no dilution effect was seen 24 h after administration of non-labelled RA. Dilution of 3H-metabolites became gradually evident and was statistically significant 4–6 days after the administration of non-labelled RA. The results are considered to be compatible with the theory that newly absorbed vitamin A does not immediately mix with endogenous vitamin A, but is temporarily metabolized (and stored) in a separate compartment. Plasma aqueous phase contained considerable radioactivity not due to vitamin A per se; it likely represented metabolites prior to excretion. It is doubtful these originated in the liver since all hepatic radioactivity was due to retinol and retinyl esters.
Publisher
Canadian Science Publishing
Subject
Physiology (medical),Pharmacology,General Medicine,Physiology
Cited by
19 articles.
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