THE FATE OF PHENOTHIAZINE IN RABBITS: I. THE DETECTION OF A NEW CONJUGATE IN RABBITS' URINE AFTER THE FEEDING OF PHENOTHIAZINE

Author:

Benham G. H.

Abstract

On feeding 5 gm. of phenothiazine to rabbits, approximately 50% of it is excreted in the urine as a colourless conjugate. This conjugate is readily hydrolysed by acids, giving the purple dye thionol and glucuronic acid. Determinations of both these entities suggest that the conjugate is composed of leuco thionol and glucuronic acid coupled together mole for mole.

Publisher

Canadian Science Publishing

Subject

Pharmacology (medical),Complementary and alternative medicine,Pharmaceutical Science

Cited by 13 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Metabolic Fate of Phenothiazine in the Marmoset (Callithrix jacchus);Drug Metabolism and Drug Interactions;2009-01

2. Mechanisms of Oxygen Metabolism;Advances in Enzymology - and Related Areas of Molecular Biology;2006-11-22

3. Fate of the anthelmintic, phenothiazine, in man;Xenobiotica;2002-01

4. Mammalian Metabolism of Orally Administered Phenothiazine;Drug Metabolism Reviews;1982-01

5. Comparative metabolism of phenothiazine in the rat (Rattus norvegicus), mouse (Mus musculus), hamster (Mesocricetus auratus) and gerbil (Gerbillus gerbillus);Comparative Biochemistry and Physiology Part C: Comparative Pharmacology;1980-01

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