Preparation and properties of poly(Nα,Nε-L-lysinediylterephthaloyl) microcapsules containing hemolysate in the nanometer range

Abstract

Poly(Nα,Nε-L-lysinediylterephthaloyl) (PPL) microcapsules containing sheep erythrocyte hemolysate (mean diameter, 380 nm) were prepared by an interfacial polymerization technique using electrocapillary emulsification as the means of producing very fine hemolysate droplets to be encapsulated. Measurements of oxygen absorption and resistance to flow were made on the PPL microcapsules. The microcapsules exhibited a myoglobin-like oxygen absorption curve and a resistance to flow higher than that of hemolysate-loaded larger PPL capsules at the same volume concentration.