Evaluation of the human health threat associated with the hepatotoxin microcystin in the muscle and liver tissues of yellow perch (Perca flavescens)

Abstract

During the summer of 2006, the western basin of Lake Erie experienced a bloom of the toxigenic cyanobacterium Microcystis aeruginosa . Across 11 sites, intracellular, particulate-bound microcystin levels in the seston increased to levels that exceeded World Health Organization guidelines for drinking water exposure (1 µg toxin·L–1). In contrast, toxin concentrations in yellow perch ( Perca flavescens ) muscle tissue (n = 68) declined from June to August, were negatively related to algal toxin levels, and never exceeded a conservative chronic exposure concentration estimated using proposed United States Environmental Protection Agency (US EPA) guidelines. Microcystin concentrations in yellow perch liver exceeded US EPA chronic exposure guidelines, were on average 125 times higher than muscle toxin concentrations per unit dry weight, and varied little throughout the summer. With current guidelines, humans do not appear to be at risk when consuming the muscle tissue of Lake Erie yellow perch collected during large-scale cyanobacterial blooms. However, this study highlights the need for a better understanding of the trophic transfer of cyanobacterial toxins through aquatic food webs in diverse ecosystems with an emphasis on understanding if these compounds could accumulate sufficiently to affect human health.