Abstract
A new alkaloid, retrorsine, has been isolated from Senecio retrorsus of South African origin. Analysis of the free base and its methiodide together with its hydrolytic products point to the empirical formula, C18H25O6N. Hydrolysis yields a new base, C8H13O2N, termed retronecine together with an acid, retronecic acid, isolated as the monolactone, C10H14O5. The base is tertiary, contains one hydroxyl (benzoyl derivative) and probably a ketonic group. The preparation of the di-p-phenylphenacyl derivative of the acid proves its dibasicity. The alkaloid, jacobine, from S. jacobaea has been isolated in a state of purity and probably has the empirical formula C18H23O5N, although this is only partly confirmed by analysis of the hydrolytic fragments. The necine derived from jacobine is shown to be identical with retronecine.An examination of S. aureus failed to show the presence of an alkaloid in tractable amounts. A system of simplified nomenclature to designate the Senecio alkaloids and their hydrolytic products is suggested.
Publisher
Canadian Science Publishing
Subject
Pharmacology (medical),Complementary and alternative medicine,Pharmaceutical Science
Cited by
16 articles.
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