Author:
Creech Hugh J.,Breuninger Evelyn R.,Adams G. A.
Abstract
Determinations were made of the chemical composition and antitumor properties of several polysaccharide fractions obtained by high speed centrifugation of aqueous extracts of the cells of Serratia marcescens following phenol extraction and trypsin digestion. The use of methods that ensured complete removal of lipid gave polysaccharides containing firmly bound amino acid residues. These were highly effective in causing complete regression of well established solid tumors in mice. The products derived primarily from the cell wall were more potent than the polysaccharides of extracellular and cytoplasmic origins. Extensive differences were also noted in the chemical composition of the polysaccharide complexes isolated from the two sources.
Publisher
Canadian Science Publishing
Cited by
22 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献