Cholinolytics in the treatment of anticholinesterase poisoning. V. The effectiveness of Parpanit with oximes in the treatment of organophosphorus poisoning

Abstract

The effectiveness of Parpanit in the treatment of organophosphorus poisoning was examined and compared with that of atropine sulfate. The potency of Parpanit was assessed in the mouse, rat, hamster, guinea pig, and rabbit against sarin, tabun, soman, CMPF, and DSDP in treatments in which the oximes P2S and TMB4 were used both singly and together. The effectiveness of the treatments utilizing both cholinolytics varied with the species used for assay, with the oxime used in combination, and with the nature and level of challenge of the organophosphorus inhibitors. The mean activity of Parpanit relative to atropine taken from a total of 102 trials indicated it to be 4.2 times as effective, with the potency ratio varying from 0.17 to 100 depending on the specific test. The acute oral toxicity of Parpanit in weanling rats was 2.9 g/kg (2.4–3.4). In a chronic toxicity study where daily oral doses as high as 1/5 LD50 were applied for 30 days, no evidence of accumulative effects could be found nor was there any evidence that the protective capacity of Parpanit against sarin was affected by the extended application of the drug.