A cluster of mutations determining erythromycin resistance in Bacillus subtilis
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Published:1973-06-01
Issue:6
Volume:19
Page:679-688
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ISSN:0008-4166
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Container-title:Canadian Journal of Microbiology
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language:en
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Short-container-title:Can. J. Microbiol.
Author:
Chu C.-Y.,Iyer V. N.
Abstract
Forty erythromycin-resistant mutants of Bacillus subtilis strain 168 were isolated as spontaneous mutants or after induction with 2-aminopurine. They showed different levels of resistance and six of these mutants were studied genetically using transformation reactions. Recombination of some pairs of mutations has a synergistic effect on resistance. All six mutants are clustered on the B. subtilis chromosome between the genes str conferring streptomycin resistance and pur B determining purine biosynthesis. Some mutations overlap at the same site. The genetic order of these ery mutations with respect to one another and a streptomycin-resistant mutation str has been determined.
Publisher
Canadian Science Publishing
Subject
Genetics,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Immunology,Microbiology
Cited by
2 articles.
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1. 2-Aminopurine;Mutation Research/Reviews in Genetic Toxicology;1980-01
2. Inhibition of DNA-induced transformation by concanavalin A in Bacillussubtilis;Biochemical and Biophysical Research Communications;1979-11