EXPERIMENTAL EXAMINATION OF THE MECHANISM OF PYRAMIDON EFFECT: III. EFFECT OF HIGH PYRAMIDON DOSES ON THE GLUTAMIC ACID–OXALOACETIC ACID TRANSAMINASE ACTIVITY IN SERUM

Author:

Fazekas Á. Gy.1,Fazekas I. Gy.1,Rengei B.1

Affiliation:

1. Institute of Forensic Medicine, Medical University of Szeged, Hungary

Abstract

In five rabbits, the changes of glutamic acid – oxaloacetic acid transaminase (SGOT) activity in serum were examined after a Pyramidon treatment in which 75% of the single lethal dose was given for 5 days, divided in three doses. Depending on the individual sensitivity, SGOT activity became from 3 to 8 times higher. This increase appeared to be a result of extensive renal lesions.

Publisher

Canadian Science Publishing

Subject

General Medicine

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